Objective  To investigate the changes of thyroid hormone level in patients with nonsmall cell lung cancer ( NSCLC) before and after chemotherapy and its clinical significance.
Methods  78 cases of NSCLC admitted between January 2009 and December 2011 were recruited in the study. The level of total triiodothyronine ( TT3 ) , total thyroxine ( TF4 ) , free triiodothyronine ( FT3 ) , free thyroxine ( FT4 ) , and thyroid stimulating hormone ( TSH) were measured by radioimmunoassay before and after chemotherapy. 35 normal subjects were recruited as control.
Results  The levels of TT3 [ ( 1. 27 ±0. 36) nmol /L vs. ( 2. 62 ±0. 46) nmol /L] and FT3 [ ( 2. 65 ±0. 76) pmol /L vs. ( 3. 79 ±0. 63) pmol /L] in the NSCLC patients were significantly lower than those in the controls ( P  lt;0. 05) , while the levels of TT4 , FT4 and TSH were similar to the controls. The level of TT3 and FT3 were correlated with clinical stage ( P  lt; 0. 05) , and not with histological grade and pathological type ( P  gt;0. 05) . The levels of TT3 and FT3 were remarkably increased in complete remission or partial remission patients after chemotherapy ( P  lt; 0. 05) .
Conclusion  Thyroid hormone measurement may be useful in the patients condition judgment and therapeutic effect monitoring.

Citation： XU Chunhua,YU Like.. Clinical Significance of Serum Thyroid Hormone Level in Patients with Non-small Cell Lung Cancer before and after Chemotherapy. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(5): 465-467. doi: DOI: 10 . 7507 /1671 -6205 . 20130112 Copy